Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 28;13:856713. doi: 10.3389/fimmu.2022.856713

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Schrottmaier, Schmuckenschlager, Pirabe and Assinger

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Indirect platelet-virus interactions. Several virus families interact with platelets via the formation of virus-IgG complexes that are recognized by platelet FcγRIIA. Antibodies against viral proteins may also act as autoantibodies by targeting platelet membrane components. Additionally, infection of endothelial cells induces expression of adhesive molecules that promote platelet adhesion. Infected endothelial cells also facilitate pro-thrombinase activity to modulate platelet activation. E-sel, E-selectin; FcγRIIA, Immunoglobulin γ Fc region receptor IIA; FN, Fibronectin; GP, Glycoprotein; HTNV, Hantaan virus; IAV, Influenza A virus; IgG, Immunoglobulin G; NS1, Non-structural protein 1; PDI, Protein disulfide isomerase; PGI₂: Prostaglandin I₂ (prostacyclin); PUUV, Puumala virus; vWF, von Willebrand factor.