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. 2022 Apr 4;2022:4987912. doi: 10.1155/2022/4987912

Table 2.

Association between neurokinin 1 receptor expression level and clinicopathological parameters.

Parameters Low or no expression High expression p
Percentage (%)/mean ± SD Percentage (%)/mean ± SD
Age (years) 51.94 ± 11.61 50.21 ± 10.41 0.350
Molecular subtype 0.493
 HER2-enriched 26 (24.1) 16 (28.6)
 Luminal A 30 (27.8) 10 (17.9)
 Luminal B 28 (25.9) 14 (25.0)
 Triple negative 24 (22.2) 16 (28.6)
Grade 0.021
 I 8 (7.4) 0 (0.0)
 II 34 (31.5) 12 (21.4)
 III 66 (61.1) 44 (78.6)
Tumor volume (cm3) 33.74 ± 52.14 49.04 ± 89.58 0.169
TNM stage 0.427
 I 4 (3.7) 3 (5.6)
 II 34 (31.8) 11 (20.4)
 III 34 (31.8) 22 (40.7)
 IV 35 (32.7) 18 (33.3)
pT stage 0.628
 T1 8 (7.4) 5 (8.9)
 T2 60 (55.6) 28 (50.0)
 T3 28 (25.9) 19 (33.9)
 T4 12 (11.1) 4 (7.1)
pN stage 0.136
 N0 27 (25.5) 17 (32.1)
 N1 32 (30.2) 7 (13.2)
 N2 20 (18.9) 13 (24.5)
 N3 27 (25.5) 16 (30.2)
Distant metastasis 0.860
 M0 72 (67.3) 35 (64.8)
 M1 35 (32.7) 19 (35.2)
Axillary lymph node metastasis 0.356
 Negative 27 (25.2) 18 (32.7)
 Positive 80 (74.8) 37 (67.3)
Lymphovascular invasion 1.000
 Negative 36 (34.0) 17 (32.7)
 Positive 70 (66.0) 35 (67.3)
ER status 0.249
 Negative 50 (46.3) 32 (57.1)
 Positive 58 (53.7) 24 (42.9)
PR status 0.249
 Negative 50 (46.3) 32 (57.1)
 Positive 58 (53.7) 24 (42.9)
HER2 status 0.742
 Negative 54 (50.0) 26 (46.4)
 Positive 54 (50.0) 30 (53.6)
DCIS history 0.331
 Absent 23 (21.7) 16 (29.6)
 Present 83 (78.3) 38 (70.4)
Family history 0.270
 No 74 (81.3) 32 (72.7)
 Yes 17 (18.7) 12 (27.3)
Adjuvant chemotherapy 0.598
 No 2 (2.4) 2 (4.9)
 Yes 81 (97.6) 39 (95.1)
Adjuvant radiotherapy 0.699
 No 49 (59.0) 26 (63.4)
 Yes 34 (41.0) 15 (36.6)
Hormonal therapy 0.252
 No 38 (45.8) 24 (58.5)
 Yes 45 (54.2) 17 (41.5)
Immunotherapy 1.000
 No 79 (95.2) 39 (95.1)
 Yes 4 (4.8) 2 (4.9)
Ki-67 0.012
 Low 71 (65.7) 25 (44.6)
 High 37 (34.3) 31 (55.4)

ER: estrogen receptor; PR: progesterone receptor; DCIS: ductal carcinoma in situ. p values in bold are those <0.05.