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. 2022 Jan 3;45(4):202–215. doi: 10.14348/molcells.2021.0206

Fig. 5. Menin downregulates metastasis-associated genes in AR-negative DU145 cells.

Fig. 5

(A) The expression of metastasis-associated genes in the GEO dataset (GDS1439). *P < 0.05; **P < 0.01; ***P < 0.001; ns, not significant. (B) Validation of the expression of metastasis-related genes identified from transcriptome data using RT-qPCR. DU145 cells were treated with a control or two independent MEN1-specific siRNAs. *P < 0.05; **P < 0.01; ***P < 0.001. (C) LNCaP cells were treated with a control or MEN1-specific siRNAs. ***P < 0.001; ns, not significant. (D) DU145 cells were treated with siRNAs targeting MEN1 or AR, as indicated. Bars show the mean mRNA level and SD. *P < 0.05; ***P < 0.001.