Table 3.
Diagnostic performance of I-FABP levels for intra-abdominal hypertension and organ failure
| Event | N | AUC (95% CI) | P | Cut-off value (95% CI) | Sensitivity (%) (95% CI) | Specificity (%) (95% CI) | ||
|---|---|---|---|---|---|---|---|---|
| All patients | ||||||||
| Maximum I-FABP | (ng/L) | IAH | 51 | 0.74 (0.60–0.85) | 0.001 | 8,337 (1,385–22,672) | 75 (53–90) | 70 (50–86) |
| (pg/nmol) | 51 | 0.74 (0.59–0.85) | 0.002 | 1.16 (0.06–1.99) | 75 (53–90) | 74 (54–89) | ||
| Median I-FABP | (ng/L) | IAH | 51 | 0.61 (0.47–0.75) | 0.185 | 1,712 (770–22,311) | 67 (45–84) | 67 (46–84) |
| (pg/nmol) | 51 | 0.64 (0.49–0.77) | 0.102 | 0.52 (0.11–3.64) | 75 (53–90) | 59 (39–78) | ||
| Maximum I-FABP | (ng/L) | Organ failure | 54 | 0.55 (0.41–0.68) | 0.571 | 24,009 (15,098–60,396) | 81 (54–96) | 34 (20–51) |
| (pg/nmol) | 54 | 0.52 (0.38–0.66) | 0.821 | 2.89 (1.86–35.27) | 75 (48–93) | 42 (26–59) | ||
| Median I-FABP | (ng/L) | Organ failure | 54 | 0.54 (0.40–0.68) | 0.598 | 2,939 (651–11,001) | 69 (41–89) | 55 (38–71) |
| (pg/nmol) | 54 | 0.55 (0.41–0.69) | 0.545 | 0.87 (0.20–3.64) | 44 (20–70) | 71 (54–85) | ||
| Patients with IAH | ||||||||
| Maximum I-FABP | (ng/L) | Organ failure | 27 | 0.55 (0.35–0.74) | 0.705 | 12,900 (265–27,951) | 63 (25–92) | 63 (38–84) |
| (pg/nmol) | 27 | 0.54 (0.34–0.73) | 0.763 | 1.58 (0.06–2.89) | 75 (35–97) | 53 (29–76) | ||
| Median I-FABP | (ng/L) | Organ failure | 27 | 0.63 (0.43–0.81) | 0.334 | 2,939 (196–8,525) | 75 (35–97) | 63 (38–84) |
| (pg/nmol) | 27 | 0.60 (0.39–0.78) | 0.462 | 0.87 (0.29–1.69) | 50 (16–84) | 79 (54–94) | ||
Data were analyzed using ROC analysis. Sensitivity and specificity are shown as percentage. AUC, cut-off value, sensitivity, and specificity are shown with 95% confidence interval within brackets
ACS, abdominal compartment syndrome; AUC, area under the receiver operating characteristics curve; CI, confidence interval; creat, creatinine; IAH, intra-abdominal hypertension; IAP, intra-abdominal pressure; I-FABP, intestinal fatty acid binding protein; N, number of patients in the analysis; ROC, receiver operating characteristic