TABLE 3.
Summary of Bayesian pharmacokinetic parameter estimates for individual subjectsa
| Parameter | 100 mg BID (n = 8) | 300 mg BID (n = 22) | 600 mg BID (n = 11) |
|---|---|---|---|
| Cmax (μg/ml) | 0.64 ± 0.17 (27) | 2.17 ± 0.47 (22) | 4.38 ± 1.19 (27) |
| AUC0–∞ (μg · h/ml) | 1.69 ± 0.85 (51) | 5.47 ± 1.38 (25) | 13.0 ± 3.00 (23) |
| Tmax (h) | 0.97 ± 0.45 (47) | 0.89 ± 0.31 (35) | 1.02 ± 0.30 (30) |
| t1/2 (h) | 0.79 ± 0.40 (51) | 0.85 ± 0.22 (25) | 1.02 ± 0.23 (23) |
| CL/F (liters/h) | 67.5 ± 19.3 (29) | 58.0 ± 13.2 (23) | 48.8 ± 11.8 (24) |
| Ka (1/h) | 1.65 ± 1.38 (83) | 1.79 ± 0.86 (48) | 1.60 ± 0.98 (61) |
a
Values are means ± standard deviation (percent coefficient of variation).