TABLE 4.

Pharmacodynamic-pharmacokinetic modeling: model parameter estimates for log₁₀ AAUCMB values of HIV-1 RNA load and CD4⁺ cell count versus AUC_0–∞ and C_max

Parameter	12-wk monotherapy group (n = 27)	All subjects (n = 41)
Log10 HIV-1 RNA load vs AUC0–∞
EC50	1.87	5.00
Emax	1.87	2.00
Adjusted r2	0.45a	0.30a
Log10 HIV-1 RNA load vs Cmax
EC50	0.74	1.63
Emax	1.89	1.88
Adjusted r2	0.35b	0.23b
Log10 CD4+ count vs AUC0–∞
EC50	0.49	0.43
Emax	0.12	0.11
E0	−0.40	−0.38
Adjusted r2	0.37b	0.33a
Log10 CD4+ count vs Cmax
EC50	0.30	0.24
Emax	0.12	0.11
E0	−0.22	−0.24
Adjusted r2	0.23c	0.23b

^aP < 0.0001. 

^bP < 0.001. 

^cP < 0.01.