TABLE 3.

Parameter values for rabbits dosed with ABLC at 10, 5, 2.5, 1.0, and 0.5 mg/kg on the basis of the best-fit curves determined from concentrations in plasma^a

Parameter	10 mg/kg	5 mg/kg	2.5 mg/kg	1.0 mg/kg	0.5 mg/kg
L(3,2) (h−1)	4,071.7 (88) [7,806–580]b	10,153 (163) [35,000–1,137]	3,425.2 (72) [6,854–1,563]	1,218.5 (34) [1,832–899]	784 (28) [1,100–605]
L(2,3) (h−1)	32.6 (130) [81.4–2.9]	61.6 (165) [21.4–6.6]	31.6 (84) [70–13]	13.2 (15) [15.8–11.3]	13.6 (3) [17.9–11.4]
P(10)c	19.2 (148) [52–0.04]	0.13 (38) [0.18–0.09]	0.71 (122) [2–0.2]	0.5 (46) [0.75–0.2]	0.003d
P(4)	672.6 (84) [1,000–17]	25 (40) [40–20]	23.5 (65) [46–12]	11.7 (22) [15.5–9.5]	10.9 (22) [13–7.9]
P(3)	1.74 (94) [3.3–0.03]	0.10 (156) [0.35–0.02]	10.7 (87) [23–0.06]	30d	30d
Clearance (ml/h)	476.2 (75)	523.2 (47)	415.2 (8.5)	248.7 (8.0)	1,918 (12)
Red blood cell area (μg · h/ml)e	448,100 (71)	111,566 (92)	34,700 (83)	19,275 (37)	10,925 (3)

^aOnly plasma was sampled from these animals. Values are mean (±coefficient of variation) for four rabbits for all doses except the 10-mg/kg dose, for which the values are for three rabbits. 

^bThe rate constant range is given in brackets. 

^cAll delay rate constants [i.e., L(7,2), L(14,7), L(15,14), L(16,15), L(17,16), and L(2,17)] for the nonlinear tissue uptake were set equal to P(10) for each rabbit, the slowest turnover time. 

^dThe value was fixed at a lower dose; therefore, no percent coefficient of variation is reported for these doses. 

^eRBC areas were derived from the best-fit curves for ABLC concentrations plasma.