TABLE 2.
Activity of gentamicin in experimental endocarditis due to E. faecalis JH2-2 or BM4281
| Regimen | Log10 CFU/g of vegetation (no. of rabbits with Gent-resistant mutants/total)a
|
|
|---|---|---|
| JH2-2 | BM4281 | |
| Controls (start of therapy) | 8.3 ± 1.2 (0/13) | 6.6 ± 1.7 (0/6) |
| Controls (end of therapy) | 9.8 ± 1.0 (0/20) | 8.5 ± 1.0 (0/10) |
| Gent, 3 mg/kg b.i.d. | 7.8 ± 1.7d (2/17) | 4.9 ± 1.7bd (6/17) |
| Gent, 6 mg/kg b.i.d. | 7.0 ± 1.0bd (3/11) | 3.8 ± 1.3cd (1/9) |
a
The mutants were selected on agar containing gentamicin (Gent) at twice the MIC. Values are means ± standard deviations.
b
P < 0.05 versus controls (start of therapy).
c
P < 0.01 versus controls (start of therapy).
d
P < 0.01 versus controls (end of therapy).