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. 2022 Apr 11;12:6049. doi: 10.1038/s41598-022-09936-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Overview of the changes in synaptic density measured by [¹⁸F]UCB-H PET (left side) and regional cerebral glucose metabolism (rCGM) measured by [¹⁸F]FDG PET (right side) in 28 selected brain regions, which are known to be involved in vestibular and sensorimotor processing. Mean normalized activity values per segmented brain region at 1, 3, 5, 7 and 9 weeks post bilateral labyrinthectomy (BL) were statistically compared using a one-way repeated measurement ANOVA with post-hoc paired t-tests and Bonferroni correction for multiple testing. Significant increases in synaptic density or rCGM are visualized in red scales (light red: p < 0.05, red: p < 0.005, dark red: p < 0.001), decreases in blue scales (light blue: p < 0.05, blue: p < 0.005, dark blue: p < 0.001). Comparison of [¹⁸F]UCB-H and [¹⁸F]FDG patterns shows a complex structure–function relationship across brain networks. [¹⁸F]FDG: [¹⁸F]fluorodeoxyglucose.