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. 2022 Apr 11;12:6049. doi: 10.1038/s41598-022-09936-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Behavioural parameters in the open field. (a) Locomotor velocity for no training and training subgroups from baseline to 9 weeks post BL. (b) Total number of zone transition from border to center zone for the no training and training subgroups at different time points post BL compared to baseline. (c) Total number of rotations per run for no training and training subgroups at different time points post BL. Values are depicted as mean + standard deviation. Significant differences (*) are derived from an ANOVA with post-hoc testing and Bonferroni correction at a level of p < 0.05. d: day, w: week.