Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 11;13:1982. doi: 10.1038/s41467-022-29175-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a Circos plots are shown: segments in circles represent individual cells yielding rearranged TCR sequences. Black lines connected clones sharing identical CDR3 sequences among individuals. Sharing of identical CDR3 sequences among six healthy donors (HD1–HD6) is shown on the left; sharing of identical CDR3 sequences among patients (UPNs 1, 8, 12, 13, 14, and 15) and patients (UPNs 4, 10, 17, 18, 19 and 24) on the right. Red and blue curves are proportional to clone sizes. b Counts of arcs connecting cells with identical CDR3 sequences among patients (n = 13) and healthy donors (n = 7) were compared pair-wisely, and there was no significant difference. Data are presented as mean values ± SEM; two-sided unpaired Mann–Whitney test. c Heatmap plot showing shared CDR3 sequences among the top 200 TCR clones of patients and healthy donors. On both x- and y-axes, samples of patients and healthy donors are listed, and adjacent grids show paired samples (pre- and post-treatments) of the same patients. Counts of identical TCR clones shared among samples are shown. Color scheme, ranging from dark orange to dark blue, indicates the number of shared TCR CDR3 sequences, from high to low.