TABLE 2.
Effect of fluconazole on recovery of CFU from kidney tissue of C. albicans-infected mice
| Isolate no.b | Fluconazole dose (mg/kg/day) | CFU per g of kidney tissue (104) at day 6 sacrifice
|
Pa for indicated pairs of doses (mg/kg/day)
|
|||
|---|---|---|---|---|---|---|
| Median | Range | 0 vs 1 | 0 vs 5 | 1 vs 5 | ||
| 1 (S) | 0 | 57 | 41–73 | |||
| 1 | 1 | 0.9–1.4 | <0.005 | |||
| 5 | 0.53 | 0.32–0.74 | <0.005 | n.s. | ||
| 2 (R) | 0 | 337 | 40–630 | |||
| 1 | 177 | 120–235 | n.s. | |||
| 5 | 583 | 300–1,100 | n.s. | n.s. | ||
| 3 (Rtr) | 0 | 45 | 3.5–78 | |||
| 1 | 5 | 3.5–7.1 | <0.05 | |||
| 5 | 1.5 | 0.7–2.4 | <0.05 | <0.01 | ||
| 4 (Rtr) | 0 | 127 | 63–192 | |||
| 1 | 0.44 | 0.3–0.6 | <0.025 | |||
| 5 | 0.08 | 0.05–0.11 | <0.025 | <0.005 | ||
a
P values were obtained using Student's t test; n.s., not significant (P > 0.05).
b
Interpretation of fluconazole susceptibilities as determined by the M27-A broth microdilution method are in parentheses. S, susceptible; Rtr, resistant with trailing growth; R, resistant.