Table 2.
Top ten significantly enriched phenotypes after schizophrenia diagnoses overall (total number of schizophrenia patients = 61,453).
| Phecode | Phecode description | Number of schizophrenia patients | Number of non-schizophrenic participants | Hazard ratio | 95% Confidence interval | P-value |
|---|---|---|---|---|---|---|
| 348.1 | Coma; stupor; and brain damage | 1017 | 12 | 87.3 | (49.4, 154.2) | 2 × 10−53 |
| 292.4 | Altered mental status | 4334 | 55 | 86.2 | (66.1, 112.4) | 2 × 10−236 |
| 348 | Other conditions of brain | 1547 | 21 | 75.8 | (49.3, 116.6) | 2 × 10−86 |
| 296.1 | Bipolar | 5990 | 108 | 60 | (49.5, 72.5) | 2 × 10−308 |
| 317.1 | Alcoholism | 1151 | 25 | 47.3 | (31.8, 70.3) | 4 × 10−81 |
| 316 | Substance addiction and disorders | 3181 | 74 | 45 | (35.7, 56.7) | 7 × 10−230 |
| 296 | Mood disorders | 1400 | 36 | 40.2 | (28.8, 55.9) | 4 × 10−106 |
| 317 | Alcohol-related disorders | 1133 | 29 | 40 | (27.6, 57.7) | 1 × 10−85 |
| 300.9 | Posttraumatic stress disorder | 1043 | 32 | 33.2 | (23.3, 47.2) | 9 × 10−85 |
| 038 | Septicemia | 731 | 25 | 30.4 | (20.4, 45.2) | 3 × 10−63 |