Table 1.
Extrapolated human dosimetry for [111In]CHX-DTPA-scFv78-Fc
| [111In]CHX-DTPA-scFv78-Fc | Average human AD extrapolations (mGy/MBq) (GA Subject) | ||||
|---|---|---|---|---|---|
| Target organ | M1 | M2* | M3 | M4 | M5 |
| Adrenals | 4.34E−01 | 3.15E−01 | 5.12E−01 | 3.57E−01 | 2.07E−01 |
| Brain | 1.73E−02 | 2.43E−02 | 2.88E−02 | 4.17E−02 | 5.91E−02 |
| Breasts | 5.01E−02 | 4.09E−02 | 6.15E−02 | 6.73E−02 | 6.77E−02 |
| Oesophagus | 1.56E−01 | 1.10E−01 | 1.74E−01 | 1.45E−01 | 1.14E−01 |
| Eyes | 1.75E−02 | 2.44E−02 | 2.90E−02 | 4.19E−02 | 5.92E−02 |
| Gallbladder Wall | 3.76E−01 | 2.20E−01 | 4.09E−01 | 2.43E−01 | 2.19E−01 |
| Left colon† | 2.78E−01 | 1.07E−01 | 4.06E−01 | 1.55E−01 | 1.01E−01 |
| Small Intestine† | 5.68E−01 | 1.55E−01 | 6.58E−01 | 1.91E−01 | 9.98E−02 |
| Stomach Wall† | 2.38E−01 | 1.30E−01 | 2.63E−01 | 1.56E−01 | 1.12E−01 |
| Right colon† | 3.06E−01 | 1.13E−01 | 4.54E−01 | 1.53E−01 | 1.20E−01 |
| Rectum† | 2.29E−01 | 6.61E−02 | 3.60E−01 | 1.35E−01 | 8.60E−02 |
| Heart wall† | 2.31E−01 | 1.28E−01 | 2.80E−01 | 2.65E−01 | 1.15E−01 |
| Kidneys† | 5.77E−01 | 2.98E−01 | 9.63E−01 | 4.58E−01 | 2.23E−01 |
| Liver† | 9.23E−01 | 5.70E−01 | 8.87E−01 | 5.68E−01 | 5.02E−01 |
| Lungs† | 1.33E−01 | 1.29E−01 | 1.78E−01 | 1.79E−01 | 1.07E−01 |
| Ovaries† | 7.31E−01 | 1.42E−01 | 7.66E−01 | 7.14E−01 | 9.82E−02 |
| Pancreas† | 3.43E−01 | 1.82E−01 | 3.78E−01 | 2.07E−01 | 1.57E−01 |
| Prostate | 6.29E−02 | 4.37E−02 | 9.16E−02 | 6.30E−02 | 7.74E−02 |
| Salivary glands | 2.15E−02 | 2.87E−02 | 3.37E−02 | 4.77E−02 | 6.66E−02 |
| Red Marrow† | 7.28E−02 | 6.73E−02 | 1.36E−01 | 1.23E−01 | 7.89E−02 |
| Osteogenic cells | 8.60E−02 | 7.58E−02 | 1.36E−01 | 1.29E−01 | 1.20E−01 |
| Spleen† | 7.14E−01 | 8.76E−01 | 7.59E−01 | 8.84E−01 | 9.71E−02 |
| Testes | 1.88E−02 | 2.56E−02 | 2.90E−02 | 3.82E−02 | 5.72E−02 |
| Thymus | 8.46E−02 | 6.78E−02 | 1.05E−01 | 1.12E−01 | 8.81E−02 |
| Thyroid | 3.88E−02 | 4.26E−02 | 5.49E−02 | 6.58E−02 | 7.21E−02 |
| Urinary bladder wall | 7.62E−02 | 4.20E−02 | 1.02E−01 | 8.27E−02 | 8.07E−02 |
| Uterus† | 9.07E−01 | 1.65E−01 | 9.53E−01 | 8.62E−01 | 9.60E−02 |
| Total body | 7.99E−02 | 5.82E−02 | 1.01E−01 | 8.39E−02 | 8.30E−02 |
| Effective dose (mSv/MBq) | 1.96E−01 | 1.16E−01 | 2.41E−01 | 1.64E−01 | 1.05E−01 |
Mouse-to-human dose extrapolations were based on time-integrated activity coefficients (TIACs) obtained from biodistribution data on mice, reported in [24]. Human TIACs were calculated for male and female subjects with five different computational methods and used as input in OLINDA/EXM v.2.1 to derive gender average (GA) organ absorbed doses (ADs) and effective doses (ED) according to the ICRP-103 [32]
*Extrapolations according to M2 were already reported in Table 2 of [24]
†Indicates source organs