Table 4.
Organ-specific allometric parameters, and corresponding uncertainties, calculated using combined experimental [68Ga]NODAGA-RGDyK biodistribution data from mice and humans
Organ | τb,m (h) | τb,m | τb,h (h) | στb,h | kb | Δkb | α' | Δα' | β′ | Δβ′ |
---|---|---|---|---|---|---|---|---|---|---|
Liver | 15.12 | 4.54 | 4.91 | 1.84 | 0.32 | 0.16 | − 0.14 | 0.06 | − 0.06 | 0.05 |
Kidneys | 0.69 | 0.21 | 2.38 | 0.66 | 3.42 | 1.39 | 0.16 | 0.05 | 0.07 | 0.08 |
Lung | 0.69 | 0.21 | 1.94 | 0.10 | 2.79 | 0.85 | 0.13 | 0.04 | 0.19 | 0.04 |
Spleen | 4.21 | 1.26 | 17.59 | 0.11 | 4.17 | 1.25 | 0.18 | 0.04 | 0.10 | 0.09 |
Heart wall | 0.47 | 0.14 | 1.28 | 0.22 | 2.74 | 0.95 | 0.13 | 0.04 | 0.26 | 0.05 |
Stomach | 0.69 | 0.21 | 4.29 | 5.45 | 6.17 | 8.06 | 0.23 | 0.16 | 0.00 | 0.06 |
Small intestine | 1.19 | 0.36 | 4.07 | 1.90 | 3.14 | 1.89 | 0.16 | 0.07 | 0.06 | 0.05 |
Left Colon | 0.60 | 0.18 | 3.50 | 1.40 | 5.87 | 2.94 | 0.22 | 0.06 | 0.06 | 0.05 |
Right colon | 0.60 | 0.18 | 3.50 | 1.40 | 5.87 | 2.94 | 0.22 | 0.06 | 0.06 | 0.05 |
Rectum | 0.60 | 0.18 | 3.50 | 1.40 | 5.87 | 2.94 | 0.22 | 0.06 | 0.06 | 0.05 |
Red marrow | 0.53 | 0.16 | 11.65 | 3.58 | 22.4 | 9.46 | 0.39 | 0.05 | 0.07 | 0.04 |
Average of all values | 0.17 (αnew) | 0.06 | 0.08 (βmean) | 0.05 |