Table 2.
Phenobarbital detoxification and supportive therapy
| Total, N = 355 (%) | Men, N = 203 (%) | Women, N = 152 (%) | P value | |
|---|---|---|---|---|
| PHB equivalents at admission (mg/day), mean (± SD) | 1205.76 ± 1456.57 | 1306.55 ± 1647.54 | 1071.16 ± 1144.89 | 0.132 |
| Hospitalisation length (days), mean (± SD) | 8.25 ± 3.66 | 8.04 ± 3.39 | 8.53 ± 3.98 | 0.213 |
| PHB use, mean (± SD) | ||||
| Start dose (mg/day) | 221.83 ± 67.82 | 229.31 ± 67.78 | 211.84 ± 66.79 | 0.016 |
| In-hospital treatment (days) | 4.12 ± 3.04 | 3.74 ± 2.71 | 4.63 ± 3.37 | 0.006 |
| Discharge dose (mg/day) | 90.21 ± 64.31 | 88.67 ± 64.83 | 92.27 ± 63.77 | 0.602 |
| Out-hospital treatment (days) | 14.45 ± 17.40 | 13.10 ± 15.91 | 16.24 ± 19.13 | 0.093 |
| Total treatment duration (days) | 18.57 ± 18.56 | 16.84 ± 16.59 | 20.87 ± 20.73 | 0.043 |
| Supportive BZD | ||||
| Yes | 150 (42.25) | 85 (41.87) | 65 (42.76) | 0.160 |
| Association | 41 (11.55) | 29 (14.29) | 12 (7.89) | |
| No | 164 (46.20) | 89 (43.84) | 75 (49.34) | |
| Supportive CDZ | ||||
| Yes | 141 (39.72) | 85 (41.87) | 56 (36.84) | 0.338 |
| No | 214 (60.28) | 118 (58.13) | 96 (63.16) | |
| Start dose (mg/day), mean (± SD) | 52.98 ± 26.53 | 58.94 ± 26.41 | 43.93 ± 24.25 | 0.001 |
| Discharge dose (mg/day), mean (± SD) | 29.93 ± 21.40 | 29.65 ± 21.01 | 30.36 ± 22.15 | 0.848 |
| In-hospital duration (days), mean (± SD) | 4.12 ± 2.88 | 3.75 ± 2.64 | 4.68 ± 3.14 | 0.061 |
| BZD-ZD free status at discharge | ||||
| Yes | 230 (64.79) | 130 (64.04) | 100 (65.79) | 0.733 |
| No | 125 (35.21) | 73 (35.96) | 52 (34.21) | |
| Supportive GBP | ||||
| Yes | 146 (41.13) | 88 (43.35) | 58 (38.16) | 0.325 |
| No | 209 (58.87) | 115 (56.65) | 94 (61.84) | |
| Start dose (mg/day), mean (± SD) | 363.51 ± 234.20 | 367.41 ± 254.85 | 357.62 ± 201.03 | 0.804 |
| Discharge dose (mg/day), mean (± SD) | 803.35 ± 279.09 | 787.78 ± 285.54 | 827.12 ± 269.63 | 0.402 |
| Supportive TZD | ||||
| Yes | 68 (19.15) | 27 (13.30) | 41 (26.97) | 0.001 |
| No | 287 (80.85) | 176 (86.70) | 11 (73.03) | |
| Supportive psychiatric therapy | ||||
| Anti-depressive | 55 (15.49) | 24 (11.82) | 31 (20.39) | < 0.001 |
| Anti-psychotic | 39 (10.99) | 23 (11.33) | 16 (10.53) | |
| Stabiliser | 28 (7.89) | 17 (8.37) | 11 (7.24) | |
| Association | 158 (44.51) | 80 (39.41) | 78 (51.32) | |
| No therapy | 75 (21.13) | 59 (29.06) | 16 (10.53) | |
BZD benzodiazepine, CDZ chlordiazepoxide, GBP gabapentin, IQR interquartile range, PHB phenobarbital, SD standard deviation, TZD trazodone, ZD z-drug