FIGURE 2.

Aspirin + cangrelor does not prevent occlusive thrombosis triggered by both collagen and tissue factor. Whole blood was treated with aspirin + cangrelor (A + C) before perfusion across collagen and tissue factor. Images of platelet (and leukocyte) and fibrin accumulation are shown in (A) and are representative of six independent experiments using blood from different donors. Mean platelet (green) and fibrin (pink) accumulation ± standard deviation (SD), and mean flow rate are shown in the panels to the right (SD is shaded are for flow rate; n = 6). (B) The platelet and fibrin integrated density values at 24 minutes. The differences were not statistically significantly different. (C) Time to occlude for each experiment. All 12 channels occluded within the 24 minutes of each experiment. The time to occlusion was not significantly different following treatment with A + C. DMSO, dimethyl sulfoxide