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. 2022 Mar 29;9:852835. doi: 10.3389/fmed.2022.852835

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Copyright © 2022 Wang, Ma, Luo, Yang, Upreti, Cheng, Cui, Liu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Three-dimensional plane view of the area with different K^trans value between groups. (A) The right insular region presents significantly higher K^trans value in the SLE group than that of the HC group. (B) The right insular region presents significantly higher K^trans value in the SLE patients with depression group than that of the patients without depression and the HC group. (C) The right insular region presents significantly higher K^trans value in the SLE patients with anxiety group than that of the patients without anxiety and the HC group. *P = 0.005, cluster size > 100. L, left; R, right.