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Agonist potency rations for CGRP, AM and AM2 at the three different CLR-RAMP complexes. The log Potency ratios (as determined from cAMP accumulation assays) are defined as log(EC50 AM2/EC50 agonist). Data compiled from Weston et al., (2016), Garelja et al., (2020), Clark et al., (2021) and Harris et al., (2021). HEK293T cells expressing CLR-Nluc are shown in cyan, HEK293 expressing CLR-Nluc are shown as magenta and HEK293T cells expressing HA-CLR are shown in brown.
