TABLE 2.
Characteristics and antiretroviral treatment for patients whose isolates displayed the Q151M or T69S-SS mutationa
| Mutation | Patient | Sex | Origin | Transmission route | Yr of first HIV detection | Date (mo/yr) of Q151M or T69S-SS detection | Viral load (log10 no. of RNA copies/ml | CD4 count (no. of cells/μl)b | Treatment duration (mo)c | Antiretroviral treatmentd |
|---|---|---|---|---|---|---|---|---|---|---|
| Q151M | IT2 | M | I | Homosexual | 1992 | 2/1993 | ND | 207 | 2 | ZDV-ddC |
| Q151M | IT1 | M | I | IVDU | 1988 | 10/1993 | 5.5 | 360 | 42 | ZDV/ZDV-ddI |
| Q151Q/M | SP1 | M | E | Homosexual | 1990 | 3/1996 | 5.3 | 50 | 8 | ZDV-ddC/ZDV-ddC-IDV |
| Q151M | SP2 | M | E | IVDU | 1986 | 2/1995 | 2.3 | 640 | 17 | ZDV/ZDV-d4T |
| Q151M | SW1 | M | S | Homosexual | 1983 | 3/1995 | 5 | 430 | 7 | ZDV/ZDV-ddI/ZDV-d4T-IDV/3TC-d4T-RTV-SQV |
| Q151M | SW2 | M | S | Homosexual | 1987 | 10/1995 | 4.2 | 6 | 34 | ZDV/ZDV-ddI/ddI/ZDV-ddI/ddI/ddI-3TC/ddI-3TC-IDV/ZDV-d4T-3TC-IDV/ZDV-d4T-3TC-SQV-RTV/d4T-3TC-SQV-RTV |
| T69S-SS | SW3 | M | S | Homosexual | 1989 | 8/1995 | 5.1 | 60 | 20 | ZDV/ZDV/ZDV-ddI/−/ZDV-ddI/ZDV-ddI-3TC/ZDV-ddI-3TC-IDV |
| T69S-SS | CHG | F | Z | Heterosexual | 1990 | 4/1995 | 3.8 | 293 | 51 | ZDV/ddI/−/ZDV-ddC/ZDV-3TC/d4T-3TC |
Abbreviations: M, male; F, female; I, Italy; E, Spain; S, Sweden; Z, Switzerland; IVDU, intravenous drug user; ND, not determined; ZDV, zidovudine; ddI, didanosine; ddC, zalcitabine; d4T, stavudine; 3TC, lamivudine; SQV, saquinavir; IDV, indinavir; RTV, ritonavir.
At the time that the Q151M or T69S-SS mutation was first identified; for viral load first available value is given.
Total duration of treatment with nucleoside analogues before Q151M or T69S-SS was identified retrospectively.
Slashes denote successive treatments, minus signs indicate no treatment, and hypens mark combination treatments. The presence of Q151M or T69S-SS is noted by underscores; the treatments that the patients were receiving at the time the original samples (that were included in the screening) were obtained are in boldface type.