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. 2022 Feb 28;36(2):109–119. doi: 10.7555/JBR.36.20210125

Table 6. Stability of clopidogrel, 2-Oxo-CLP, and CAMD in human plasma.

Analytes Added (ng/mL) Found (ng/mL)
At –80 °C
for 45 days
After
three-thaw
cycles
Plasma at room
temperature
for 8 hours
Extract at room
temperature
for 8 hours
Extract in the
auto-sampler at
4 °C for 24 hours
All the data are presented as mean±SD. 2-Oxo-CLP: 2-oxo-clopidogrel; CAMD: clopidogrel active metabolite derivative.
Clopidogrel 0.2 0.2±0.0 0.2±0.0 0.2±0.0 0.2±0.0 0.2±0.0
10 10.1±0.2 10.1±0.8 10.4±0.8 10.0±1.4 10.0±0.8
2-Oxo-CLP 2 2.0±0.1 1.9±0.2 2.2±0.4 2.1±0.2 2.2±0.2
50 50.6±1.2 51.0 ± 3.9 52.2±5.1 50.1±7.6 49.0±3.7
CAMD 2 2.0±0.1 1.9 ± 0.2 2.2±0.4 2.0±0.2 2.1±0.2
50 50.4±1.2 51.5±3.8 51.1±4.9 49.6±7.7 50.1±3.9