Table 6. Stability of clopidogrel, 2-Oxo-CLP, and CAMD in human plasma.
| Analytes | Added (ng/mL) | Found (ng/mL) | ||||
| At –80 °C
for 45 days |
After
three-thaw cycles |
Plasma at room
temperature for 8 hours |
Extract at room
temperature for 8 hours |
Extract in the
auto-sampler at 4 °C for 24 hours |
||
| All the data are presented as mean±SD. 2-Oxo-CLP: 2-oxo-clopidogrel; CAMD: clopidogrel active metabolite derivative. | ||||||
| Clopidogrel | 0.2 | 0.2±0.0 | 0.2±0.0 | 0.2±0.0 | 0.2±0.0 | 0.2±0.0 |
| 10 | 10.1±0.2 | 10.1±0.8 | 10.4±0.8 | 10.0±1.4 | 10.0±0.8 | |
| 2-Oxo-CLP | 2 | 2.0±0.1 | 1.9±0.2 | 2.2±0.4 | 2.1±0.2 | 2.2±0.2 |
| 50 | 50.6±1.2 | 51.0 ± 3.9 | 52.2±5.1 | 50.1±7.6 | 49.0±3.7 | |
| CAMD | 2 | 2.0±0.1 | 1.9 ± 0.2 | 2.2±0.4 | 2.0±0.2 | 2.1±0.2 |
| 50 | 50.4±1.2 | 51.5±3.8 | 51.1±4.9 | 49.6±7.7 | 50.1±3.9 | |