Fig. 7. Lycium barbarum polysaccharide (LBP) (4.0 mg/mL)-induced ferroptosis through the light-chain subunit of cystine/glutamate antiporter system Xc - (xCT)/glutathione peroxidase 4 (GPX4) pathway in MCF-7 cells. (a‒c) Expression levels and quantification of xCT and GPX4 after co-treatment of cells with LBP and Erastin (xCT inhibitor); (d‒f) Expression levels and quantification of xCT and GPX4 after co-treatment of cells with LBP and RSL3 (GPX4 inhibitor); (g) Schematic representation of LBP-induced ferroptosis and related mechanisms in breast cancer cells. Data are expressed as mean±standard deviation (SD), n=3. * P<0.05, ** P<0.01. GSH: glutathione; ROS: reactive oxygen species.
