Fig. 8. Protein‍–‍protein interaction network of DEGs enriched in the apoptosis pathway. The nodes represent DEGs, and the node size represents gene score calculated by maximal clique centrality (MCC) arithmetic. Genes with high degrees tend to be hub genes. The red and green nodes represent upregulated and downregulated genes, respectively. The edges represent proteins' association, and their thickness indicates the interaction strength of data support, including text mining, experiments, databases, co-expression, neighborhood, gene fusion, and co-occurrence. The screening threshold was set as 0.4. The top 50 pathways with corrected P-value of <0.05 were considered the significant pathways, and these were presented. The rich factor represents the number of DEGs that exist in this pathway accounting for the total number of genes of this pathway. DEG: differentially expressed gene.