Table 2.
Univariate and multivariable Cox regression analysis of OS and BCSS from 216 patients with breast cancer
| Covariate | Univariate analysis |
Multivariable analysis |
||||||
|---|---|---|---|---|---|---|---|---|
| OS |
BSCC |
OS |
BCSS |
|||||
| HR (95% CI) | P a | HR (95% CI) | P a | HR (95% CI) | P b | HR (95% CI) | P b | |
| Age group | ||||||||
| ≤55 years | 1.00 (Referent) | 1.00 (Referent) | — | — | ||||
| >55 years | 0.99 (0.54 to 1.82) | .97 | 0.62 (0.30 to 1.27) | .19 | — | — | — | — |
| Pathological disease stage | ||||||||
| I | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) | ||||
| II | 2.36 (0.88 to 6.29) | .09 | 10.39 (1.32 to 82.05) | .03 | 2.41 (0.90 to 6.43) | .08 | 10.64 (1.35 to 84.15) | .02 |
| III | 6.64(2.58 to 17.10) | <.001 | 34.81 (4.59 to 263.84) | <.001 | 9.34 (3.57 to 24.47) | <.001 | 48.73 (6.35 to 347.14) | <.001 |
| IV | 29.85 (9.33 to 85.47) | <.001 | 162. 61 (19.24 to 1374.60) | <.001 | 38.02 (11.44 to 126.37) | <.001 | 208.32 (24.00 to 1808.31) | <.001 |
| Grade | ||||||||
| 1-2 | 1.00 (Referent) | 1.00 (Referent) | — | — | ||||
| 3 | 4.20 (1.76 to 10.01) | .001 | 3.97 (1.53 to 10.33) | .005 | — | — | — | — |
| Hormone receptor status | ||||||||
| Negative | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) | ||||
| Positive | 0.40 (0.20 to 0.79) | .008 | 0.48 (0.23 to 1.00) | .0495 | 0.32 (0.15 to 0.69) | .004 | 0.36 (0.16 to 0.82) | .01 |
| Estrogen receptor status | ||||||||
| Negative | 1.00 (Referent) | 1.00 (Referent) | — | — | ||||
| Positive | 0.40 (0.20 to 0.79) | .008 | 0.48 (0.23 to 1.00) | .0495 | — | — | — | — |
| Progesterone receptor status | ||||||||
| Negative | 1.00 (Referent) | 1.00 (Referent) | — | — | ||||
| Positive | 0.29 (0.13 to 0.66) | .003 | 0.31 (0.13 to 0.76) | .01 | — | — | — | — |
| HER2 status | ||||||||
| Negative | 1.00 (Referent) | 1.00 (Referent) | — | — | ||||
| Positive | 0.43 (0.13 to 1.39) | .16 | 0.16 (0.02 to 1.19) | .07 | — | — | — | — |
| Triple-negative breast cancer status | ||||||||
| Negative | 1.00 (Referent) | 1.00 (Referent) | — | — | ||||
| Positive | 2.29 (1.19 to 4.41) | .01 | 2.10 (1.02 to 4.32) | .04 | — | — | — | — |
| NDRG1 | ||||||||
| Low | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) | ||||
| High | 2.27 (1.20 to 4.29) | .01 | 2.19 (1.07 to 4.48) | .03 | 2.17 (1.10 to 4.30) | .03 | 2.27 (1.05 to 4.92) | .04 |
a
P values are based on 2-sided test from univariate Cox regression model. BCSS = breast cancer specific survival; CI = confidence interval; HR = hazard ratio, OS = overall survival.
b
P values are based on 2-sided test from multivariable Cox regression model.