Figure 1.
Odds ratio of different combinations of environmental risk score (ERS) and polygenic risk score (PRS) risk profiles across tertiles and associations with early-onset colorectal cancer (CRC) risk. Models were adjusted for age, sex, total energy consumption, study, family history, genotype platform, and principal components. The referent category is the first tertile for both the ERS and PRS. Two-sided P values per the Wald test. The error bars represent the 95% confidence intervals (CIs). OR = odds ratio.