Figure 2.

Ten-year absolute risk estimates for early-onset colorectal cancer (CRC) with varying risk factor profiles for a 40-year-old individual. Dashed lines indicate the average 10-year absolute risks of early-onset CRC estimated using Surveillance, Epidemiology, and End Results for a 40-year-old person: A) 0.21% in men and B) 0.18% in women. The environmental risk score (ERS) and polygenic risk score (PRS) combined model adjusted for age, study, total energy consumption, family history, genotype platform, and principal components. The ERS-only model adjusted for age, study, total energy consumption, and family history. The PRS-only model adjusted for age, family history, genotype platform, and principal components.