Table 3.
Model | All participants | Men | Women |
---|---|---|---|
AUC (95% CI) | AUC (95% CI) | AUC (95% CI) | |
Model 1: Family historya | 0.563 (0.555 to 0,571) | 0.568 (0.558 to 0.580) | 0.558 (0.547 to 0.569) |
Model 2: ERS per 1 SDb | 0.536 (0.519 to 0.552) | 0.546 (0.519 to 0.571) | 0.525 (0.494 to 0.543) |
Model 3: PRS per 1 SDc | 0.628 (0.613 to 0.644) | 0.621 (0.592 to 0.651) | 0.633 (0.612 to 0.655) |
Model 4: ERS and PRS per 1 SDd | 0.631 (0.615 to 0.647) | 0.629 (0.604 to 0.654) | 0.630 (0.607 to 0.652) |
The model includes family history as the predictor, adjusting for sex (for the model including all participants) and age. AUC = area under the receiver operating characteristic curve; CI = confidence interval; ERS = environmental risk score; PRS = polygenic risk score.
The model includes a z-transformed ERS as the predictor, adjusting for age, sex (for the model including all participants), total energy consumption, study, and family history.
The model includes a z-transformed PRS as the predictor, adjusting for age, sex (for the model including all participants), family history, genotype platform, and principal components.
The model includes z-transformed ERS and PRS as predictors, adjusting for age, sex (for the model including all participants), study, family history, total energy consumption, principal components, genotype platform, and a z-transformed ERS.