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. 2021 Dec 10;114(4):618–625. doi: 10.1093/jnci/djab224

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Stratified analysis by IPLC stage: adjusted survival curves for overall mortality among patients with second primary lung cancer vs single primary lung cancer in SEER. Subgroup of patients with early stage of IPLC (n = 133 445) and patients with advanced stage of IPLC (n = 11 551). Overall mortality was estimated using multivariable Cox regression with time-varying SPLC adjusting for sex, race, age, stage, and histology at IPLC. Interaction was assessed between IPLC stage and SPLC diagnosis on overall survival using a 2-sided likelihood ratio test. CI = confidence interval; HR = adjusted hazard ratio; IPLC = initial primary lung cancer; SEER = Surveillance, Epidemiology, and End Results; SPLC = second primary lung cancer.