Table 7.
Cardioprotective effects and mechanisms of α-Bisabolol.
| Cardioprotective Effects | ||||
|---|---|---|---|---|
| Compound | Dose/Route/ Duration |
Model | Major Mechanisms | Reference |
| α-Bisabolol | 25 mg/kg, i.p for 10 days | Isoproterenol (85 mg/kg, s.c. for 2 days) induced myocardial infarction in rats | ↓ LDH, ↓ infarct size ↓ TBARS, ↑ SOD, CAT, ↓ β-glucuronidase, β-galactosidase, cathepsin-B &D, ↓ TNF-α, IL-6, IL-1β, iNOS and COX-2, ↑ IL-10, ↓ NLRP3, (-) NFκB/MAPK, ↑ Beclin-1, LC3BI/II, ↓ p-mTOR |
[91] |
| α-Bisabolol | 25 mg/kg, i.p daily for 10 days | Isoproterenol (85 mg/kg, s.c. for 2 days) induced myocardial infarction in rats | ↑ CK and LDH, ↓ LOOH, TBARS, ↑ SOD, catalase and GSH, ↓ Ca2+ overload ↓ mitochondrial swelling, ↑ ATP, ↑ ICDH, SDH, MDH, α-KGDH, and complexes I-IV, ↓ Bax, P53, APAF-1, active caspase-3 and 9, ↑ Bcl-2 |
[92] |
| α-Bisabolol | 25 mg/kg, i.p daily for 10 days | Isoproterenol (85 mg/kg, s.c. for 2 days) induced myocardial infarction in rats | ↓ CK ↓ TBARS and LOOH ↑ GSH and vitamin-C ↓ HR, SBP and DBP |
[93] |
Symbols indications: ↑; increase, ↓; decrease, (-); reduce.