Table 8.

Statement regarding extra-skeletal actions of vitamin D in adults.

Consensus Statement	Consensus Voting Scale	Level of Agreement
Results from observational studies consider a low 25(OH)D concentration as a potential risk marker for several diseases such as cancer incidence and mortality, cardiovascular diseases, diabetes mellitus and its comorbidities, chronic autoimmune diseases, metabolic syndrome, acute respiratory tract infections, neurological diseases and total mortality. Results from meta-analyses of RCTs suggest that beyond musculoskeletal-effects, vitamin D supplementation may have beneficial extra-skeletal effects regarding acute respiratory tract infections and cancer mortality. In patients with or at risk of different types of cancer, certain cardiovascular diseases, diabetes mellitus and its comorbidities, chronic autoimmune diseases, certain neurological diseases and recurrent acute respiratory tract infections, a screening of vitamin D deficiency should be considered, and preventive vitamin D supplementation may be considered.	9 (strongly agree)	60%
	8	10%
	7 (agree)	30%
	6	0%
	5 (neutral)	0%
	4	0%
	3 (disagree)	0%
	2	0%
	1 (strongly disagree)	0%
Overall agreement 100%, consensus endorsed