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. 2022 Apr 4;11(4):bio059091. doi: 10.1242/bio.059091

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Chromatin within a nucleus is hierarchically organised. (A) Chromosomes occupy distinct regions or territories within the nucleus known as chromosome territories. (B) Chromosomes are partitioned into compartments, with compartment A being associated with the interior of the nucleus and active chromatin, compartment B being associated with inactive chromatin located near the nuclear lamina. (C) The genome is further partitioned into TADs, with interactions between enhancers and their target genes preferentially occurring within TADs. At several TADs, enhancers regulating the expression of a gene can be located throughout its TAD – indicating that TADs can directly correspond to gene regulatory domains.