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. 2022 Apr 4;11(4):bio059091. doi: 10.1242/bio.059091

Fig. 2.

Fig. 2.

The regulatory domain of the key developmental transcription factor Shh. Visualisation of the region chr5:28Mb-30Mb in mouse (mm10) which contains multiple genes; displaying the Hi-C interaction matrix in neural progenitor cells (NPC), TADs and locations of validated Shh enhancers. Shh is under the control of multiple enhancers located throughout its TAD, some of which are located closer to other genes than Shh, which would be erroneously assigned by using nearest gene assignment.