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The regulatory domain of the key developmental transcription factors Irx3/5 and 6. Visualisation of the region chr8:90.5Mb-93Mb in mouse (mm10); displaying Hi-C interaction matrix from in neural progenitor cells (NPC), location of interactions as identified 4C involving the promoters of Fto and Irx3 (Smemo et al., 2014). Irx3 is regulated by multiple regulatory elements located throughout its TAD, including elements located within the introns of Fto.
