Table 2.

Intra and intergroup changes in the INT and CON-group after 6 and 12 months compared to baseline focusing on individual risk groups.

	Baseline		6 Months			12 Months
	INT	CON	INT	CON	P (INT vs. CON)	INT	CON	P (INT vs. CON)
SBP (mmHg) ‡
ITT (n = 180 vs. 89)	134 ± 11	133 ± 10	−8.6 [−11.1; −7.3] ***	−7.9 [−10.9; −5.4] ***	0.652	−7.3 [−9.2; −5.3] ***	−3.3 [−5.9; −0.8] *	0.049
PP (n = 119 vs. 55)	134 ± 12	133 ± 11	−10.6 [−11.4; −9.6] ***	−9.9 [−13.7; −6.3] ***	0.534	−8.8 [−11.4; −6.1] ***	−4.0 [−7.9; −0.1] *	0.031
DBP (mmHg) †
ITT (n = 225 vs. 117)	94 ± 10	92 ± 8	−4.6 [−5.7; −3.2] ***	−1.6 [−3.3; −0.1] *	0.009	−3.7 [−4.9; −2.5] ***	−1.4 [−3.1; 0.2]	0.028
PP (n = 146 vs. 73)	94 ± 9	92 ± 7	−5.8 [−7.0; −4.1] ***	−2.1 [−4.1; −0.2] *	0.003	−4.4 [−5.8; −3.0] ***	−1.5 [−3.4; 0.5]	0.019
Resting HR (bpm) $
ITT (n = 208 vs. 94)	78 ± 8	77 ± 8	−4.0 [−5.3; −2.7] ***	−1.6 [−3.5; 0.4]	0.045	−2.7 [−4.0; −1.4] ***	−2.4 [−4.3; −0.4] *	0.783
PP (n = 137 vs. 60)	77 ± 8	78 ± 8	−5.0 [−6.6; −3.4] ***	−3.6 [−6.3; −1.2] **	0.353	−3.4 [−4.9; −1.6] ***	−4.5 [−6.9; −2.3] ***	0.240
PWV (m/s) $
ITT (n = 194 vs. 98)	8.4 ± 0.7	8.2 ± 0.7	−0.18 [−0.28; −0.08] ***	−0.07 [−0.20; 0.13]	0.043	−0.10 [−0.18; −0.03] *	−0.01 [−0.11; 0.10]	0.110
PP (n = 137 vs. 65)	8.3 ± 0.7	8.3 ± 0.8	−0.25 [−0.36; −0.16] ***	−0.11 [−0.27; 0.15]	0.049	−0.09 [−0.18; 0.01]	0.02 [−0.12; 0.16]	0.200

Data are shown as mean ± SD and mean [95% CI]. *** p < 0.001 vs. baseline; ** p < 0.01 vs. baseline; * p < 0.05 vs. baseline. ^‡ hypertensive and prehypertensive participants (>120 mmHg) were considered; ^† hypertensive and prehypertensive participants (>80 mmHg) were considered; ^$ upper two tertiles (with highest values); Differences in changes after 6 and 12 months between both groups were analyzed using ANCOVAs adjusting for baseline values. DBP, diastolic blood pressure; HR, heart rate; ITT, intention to treat; PP, per protocol; PWV, pulse wave velocity; SBP, systolic blood pressure.