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. 2022 Apr 6;14(7):1528. doi: 10.3390/nu14071528

Figure 3.

Figure 3

CRABP1-CaMKII signalsome. Upon cardiac or neuronal stimulation and subsequent intracellular Ca2+ increase to activate CaMKII, CRABP1 directly competes with calmodulin (CaM) to dampen CaMKII enzyme activity to ultimately modulate cardiac and/or neuronal stimulation. CRABP1: Cellular Retinoic Acid Binding Protein 1, RA: retinoic acid, CaMKII: calcium-calmodulin-associated dependent kinase 2.