Table 2.

Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0

Classification	Magnitude of the adverse event
Grade 1	Mild adverse event. Asymptomatic or mild clinical symptoms or just an observation; intervention not indicated.
Grade 2	Moderate adverse event. Minimal, local or non-invasive intervention indicated.
Grade 3	Serious or medically significant adverse event, but not immediately life-threatening. Hospitalization or hospitalization prolongation indicated; important limitation of self-care.
Grade 4	Adverse event with risk of mortality or disability.
Grade 5	Death associated with an adverse event.