TABLE 1.

Single-drug and combination therapy for experimental meningitis caused by penicillin-resistant Streptococcus pneumoniae

Antibiotic	No. of rabbits	Initial titer (log10 CFU/ml [mean + SD])	Killing rate (Δlog10 CFU/ml · h [mean ± SD])	Killing rate/8 h (log10 CFU/ml [mean ± SD])
Controls	10	6.30 ± 0.64	+0.04 ± 0.10a	+0.28 ± 0.15a
Alatrofloxacin	9	6.36 ± 0.79	−0.37 ± 0.15	−3.04 ± 0.19
Ceftriaxone	9	5.64 ± 0.73	−0.32 ± 0.12	−2.25 ± 0.50
Vancomycin	12	6.30 ± 1.12	−0.36 ± 0.19	−3.25 ± 0.45
Vancomycin + ceftriaxone	9	6.15 ± 0.20	−0.53 ± 0.22	−4.00 ± 0.86bc
Alatrofloxacin + ceftriaxone	10	6.01 ± 0.74	−0.67 ± 0.16b	−5.05 ± 0.60bc

^aP < 0.05 versus all groups. 

^bP < 0.05 versus all monotherapies. 

^cP < 0.05 for alatrofloxacin + ceftriaxone versus vancomycin + ceftriaxone.