TABLE 3.

Cardiac events by LMNA pathogenic variant

	Odds Ratio (95% CI); P value	Odds Ratio (95% CI); P value *
LMNA variant compared to non-LMNA
Arrhythmia	2.93 (1.29–6.64); 0.010	3.77 (1.45–9.83); 0.007
Atrial fibrillation/ Atrial flutter	5.30 (1.11–25.39); 0.037	5.78 (1.04–32.16); 0.045
Conduction abnormality	1.90 (0.70–5.17); 0.211	2.20 (0.71–6.85); 0.173
	Odds Ratio (95% CI); p value	Odds Ratio (95% CI); P value †
Non-482 LMNA variant compared to 482
Arrhythmia	3.37 (1.12–10.08); 0.030	4.74 (1.41–15.98); 0.012
Atrial fibrillation/ Atrial flutter	5.44 (1.24–23.95); 0.025	17.67 (2.45–127.68); 0.004
Conduction abnormality	3.77 (1.05–13.57); 0.042	5.71 (1.37–23.76); 0.017

^*Adjusted for age at cardiac examination, BMI, comorbidities. Sex distribution and diabetes were not included in the model since >85% are diabetics and >80% are females. In addition, sex distribution was not different between LMNA and non-LMNA group, and the sample size did not allow for extra parameters in the model. Seven patients with no complete gene sequencing for LMNA are excluded.

^†Adjusted only for age at cardiac examination due to limited sample size. Seven patients with no complete gene sequencing for LMNA are excluded.