TABLE 4.

Clinical Characteristics and Codon 482 Variants of the LMNA Gene

	Non-482 variant (n = 22)	482 variant (n = 38)	P value
Cardiac examination age, y	42 (31–49)	47 (33–57)	0.094
Sex, Females	17 (77)	31 (82)	0.744
BMI, kg/m2	22.9 (19.6–27.3)	24.8 (21.9–28.3)	0.123
Diabetes Mellitus	19 (86)	31 (82)	0.732
Hypertension	15 (68)	27 (71)	1.000
Pancreatitis	6 (27)	6 (16)	0.327
Glucose, mg/dL	114 (93–171)	142 (101–184)	0.193
HbA1c, %	6.8 (5.8–8.1)	7.7 (6.0–8.7)	0.337
Triglycerides, mg/dL	190 (126–410)	323 (196–485)	0.079
Total cholesterol, mg/dL	202 (159–268)	193 (160–226)	0.544
LDL cholesterol, mg/dL	96 (75–130)	93 (63–125)	0.520
HDL cholesterol, mg/dL	39 (35–45)	36 (30–44)	0.167
Non-HDL cholesterol, mg/dL	149 (116–207)	149 (116–187)	0.713
Leptin†, ng/mL	4.2 (1.5–8.5)	3.1 (1.4–7.4)	0.773
Ischaemic heart disease	6 (27)	8 (21)	0.753
Myocardial infarction	5 (23)	1 (3)	0.021
Stroke	2 (9)	2 (5)	0.619
Arrhythmia	14 (64)	13 (34)	0.034
Atrial fib/flutter	7 (32)	3 (8)	0.029
PVC	2 (9)	5 (13)	1.000
PAC/SVPC	3 (14)	2 (5)	0.346
Sinus arrhythmia	4 (18)	6 (16)	1.000
Conduction abnormality	8 (36)	5 (13)	0.052
Axis deviation	5 (23)	1 (3)	0.021
Prolonged QT	6 (27)	7 (18)	0.520
Cardiomyopathy	8 (36)	2 (5)	0.003
Congestive heart failure	8 (36)	3 (8)	0.012
LV hypertrophy‡	3 (17)	10 (32)	0.282
Diastolic dysfunction‡	5 (28)	4 (13)	0.400
Valvular heart disease‡	10 (56)	10 (33)	0.441

Note: Values are median (interquartile range) or n (%).

BMI indicates body mass index; LDL, low density lipoprotein; HDL, high density lipoprotein; HbA1c, haemoglobin A1c; PVC, premature ventricular complex; PAC, premature atrial complex; SVPC, supraventricular premature complex.

^†Leptin levels are before metreleptin treatment closest to cardiac evaluation.

^‡Echocardiogram is available in 48 patients (18 with non-codon 482 variant and 30 patients with codon 482 variant).