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. Author manuscript; available in PMC: 2022 Apr 12.
Published in final edited form as: Adv Drug Deliv Rev. 2021 May 29;175:113803. doi: 10.1016/j.addr.2021.05.013

Figure 5. Polymer and particulate approaches to improve adjuvant potency.

Figure 5.

(A) Effect of varying TLR7 agonist density on lymph node residence time of the particle and varying size and architecture of the polymer on antigen-specific T cell response. (B) polymeric nanogel approach toward enhanced lymph node delivery and retention. (C) Adsorption to alum resulting in ‘depot’ effect which minimizes conc of TNF-α in the blood upon administration.