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. Author manuscript; available in PMC: 2022 Apr 12.
Published in final edited form as: Semin Nephrol. 2020 Mar;40(2):188–198. doi: 10.1016/j.semnephrol.2020.01.009

Figure 2.

Figure 2.

Schematic of day 14 (D14) kidney (left) organoid nephrons expressing segment-specific markers based on findings from Przepiorski et al15 in comparison with the mature human kidney (right). The glomerulus, expresses NPHS1 and WT1 in the podocytes, and PECAM1 in the endothelial cells. Segments 1 to 3 of the proximal tubule (S1, S2, S3) expressed LRP2 and Lotus tetragonologus lectin. The thick ascending limb expressed SLC12A1 and UMOD. The loop of Henley was not present in the kidney organoids. The distal convoluted tubule expressed UMOD, GATA3, and CALB1. The connecting tubule expressed GATA3 and CALB1. The CD expressed CALB1 and GATA3. CDH1 expressed TAL to CD. Abbreviations: CALB1, calbindin 1; CNT, connecting tubule; DCT; distal convoluted tubule; Glom, glomerulus; LoH, loop of Henley; LRP2, LDL receptor related protein 2; LTL, Lotus tetragonologus lectin; PECAM1, platelet and endothelial cell adhesion molecule-1; PT, proximal tubule; TAL, thick ascending limb; UMOD, uromodulin; WT1, Wilms’ tumor-1.