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. Author manuscript; available in PMC: 2022 Apr 12.
Published in final edited form as: Cancer Lett. 2019 Jul 18;461:123–131. doi: 10.1016/j.canlet.2019.07.012

Figure 2: Maturation of Notch receptors.

Figure 2:

Notch receptors mature in the endoplasmic reticulum (ER) and Golgi complex. Fucosylation is essential and occurs through the interaction between the Notch precursor protein and O-fucosyltransferase 1 (OFUT1 in Drosophila, POFUT1 in mammals) in the ER. The fucosylated Notch precursor is then transported to the Golgi complex, where proteolytic cleavage by Furin-like convertase at site 1 (S1) occurs. Finally, the matured Notch is transported to the cell surface.