Fig. 4.

Baseline metaproteomic signatures associated with HIV control after ART interruption. Comparison of a Clostridiales and b Bacteroidales abundances derived from gut metaproteome data in controllers and non-controllers at study entry. No differences in Clostridiales or Bacteroidales proteome at the order-level were observed. c Baseline levels of Clostridiales proteins distinguished controllers from non-controllers in a hierarchical clustering. d Functional annotation of Clostridiales bacterial proteins using KEGG gene ontology identified baseline differences in cellular metabolism pathways between groups. Abbreviations: C = controllers, NC = non-controllers, SC = spectral count. Unadjusted p values are shown. Benjamini–Hochberg multiple hypothesis correction for p values ≤ 0.05 are provided in Additional file 2: Dataset S7