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. 2022 Apr 11;23:91. doi: 10.1186/s12931-022-02001-0

Table 3.

Cox proportional hazard regression comparing mortality and hospitalizations among patients with idiopathic pulmonary fibrosis with and without metformin use

Rate per 100 (95% CI)
Before propensity score matching After propensity score matching Hazard ratio (95% CI) p value
No metformin (n = 2222) Metformin (n = 1377) No metformin (n = 1100) Metformin (n = 1100)
Death 25.1 (23.3, 27.1) 10.5 (8.7, 12.5) 20.6 (18.4, 23.2) 10.5 (8.5, 12.8) 0.46 (0.36, 0.58)  < 0.001
Hospitalization 76.1 (72.0, 80.6) 55.12 (50.4, 60.3) 64.3 (59.2, 69.9) 57.8 (52.4, 63.8) 0.82 (0.72, 0.93) 0.003