Fig. 8 –
Deformation-induced changes in tissue stiffness. Line plots of (a) effective elastic modulus Eeff and (b) normalized effective elastic modulus ENeff. Results presented for leakiness without growth (JR→0 = 1), growth without leakiness (JR→0 = 1.2; LpS = 0), and growth with leakiness (JR→0 = 1.2). The lines labeled “State R” correspond to Eeff prior to deformation, Eeff = E (See legend in Panel a). The vertical line indicates the nominal tumor boundary. The nominal elastic modulus values are Et = 3.8 kPa and Eh = 5.4 kPa