TABLE 2.
Strain | MIC (μg/ml) | Amino acid at position:
|
|||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5 | 6 | 10 | 16 | 25 | 31 | 50 | 51 | 53 | 56 | 59 | 62 | 64 | 68 | 75 | 84 | 88 | 90 | 97 | 98 | 106 | 111 | 118 | 122 | 131 | 140 | 150 | 163 | 172 | 175 | 183 | 184 | 196 | 198 | 199 | 200 | 204 | 207 | ||
Susceptible strains | |||||||||||||||||||||||||||||||||||||||
22aa | 0.75 | D | Q | R | R | H | T | Q | P | H | M | N | L | K | V | E | M | S | K | H | G | P | V | T | G | R | C | G | G | V | E | A | C | S | K | S | R | V | I |
160a | 0.38 | .b | H | . | . | . | E | . | . | . | . | . | . | . | . | . | . | . | R | Y | . | . | . | A | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
163c | 1 | . | H | . | . | . | . | . | . | . | . | . | . | . | A | . | . | . | . | . | . | . | . | . | . | K | . | . | . | I | . | V | . | . | . | . | . | . | . |
165c2 | 1 | N | . | . | . | . | . | . | . | . | . | . | . | . | A | . | . | . | R | Y | . | . | . | A | S | . | . | . | . | I | Q | . | . | . | . | . | . | . | . |
29a | 2 | . | H | . | . | . | E | . | . | . | . | . | . | . | A | . | . | . | . | T | . | . | . | A | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
303a | 0.125 | . | . | . | . | . | E | . | . | . | . | . | . | N | A | . | . | . | . | . | . | S | . | A | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
304a | 1.5 | . | H | . | . | . | . | . | . | . | I | . | . | . | A | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | K | . | . | . | . | . |
338a | 0.094 | . | . | . | . | . | . | . | . | . | . | . | . | . | A | . | . | . | R | . | . | . | . | A | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
356a12 | 0.125 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | R | . | . | . | . | A | . | K | . | . | . | . | . | . | . | . | . | . | . | . | V |
48a | 3 | . | H | . | . | . | E | . | . | . | . | . | . | . | A | . | . | . | . | . | . | . | . | A | . | . | . | . | . | . | Q | . | . | N | . | . | . | . | . |
83a2 | 1.5 | . | . | . | . | . | . | . | . | . | . | . | . | . | A | . | . | . | R | . | . | . | . | A | . | K | . | . | . | . | . | . | . | . | . | . | . | . | . |
88c | 0.5 | N | . | . | . | . | . | . | . | . | . | . | V | . | A | . | . | . | R | Y | . | . | . | . | . | K | . | . | . | . | . | . | . | . | N | Q | G | . | . |
951 | 0.023 | . | . | . | . | . | E | . | . | . | I | . | . | . | . | . | . | . | R | . | S | . | . | A | . | . | . | . | . | . | . | V | . | . | . | . | . | . | . |
97a | 1 | . | . | . | . | . | E | . | . | R | . | . | . | N | A | . | . | . | . | T | . | S | A | A | . | . | . | . | . | I | Q | V | . | . | . | . | . | . | . |
Resistant strains | |||||||||||||||||||||||||||||||||||||||
56a | 32 | . | . | . | . | . | E | . | . | . | . | . | . | . | A | . | . | . | . | . | . | . | . | . | . | . | . | . | . | I | Q | . | . | . | . | . | . | . | . |
84a | 48 | . | . | . | . | . | E | ∗c | . | . | . | . | . | . | A | . | . | . | . | . | . | S | A | A | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
122a | 32 | . | H | . | . | . | E | . | S | . | . | . | . | . | A | . | . | . | . | . | . | S | A | . | . | K | . | . | . | . | . | . | . | . | . | . | . | I | . |
128a | 64 | . | H | . | H | . | . | . | . | . | I | . | . | . | A | . | . | . | . | T | . | S | . | . | . | K | . | . | . | . | . | . | . | . | N | H | E | . | . |
136c2 | 12 | . | . | . | . | . | E | . | . | . | . | . | . | . | A | . | . | . | . | . | S | . | . | . | . | K | . | . | . | . | ∗ | . | . | . | . | . | . | . | . |
313c | 32 | . | . | . | . | . | . | . | . | . | I | . | . | . | A | . | I | . | R | . | . | . | . | A | . | . | Y | . | . | . | . | . | . | . | . | . | . | . | . |
318a2 | 32 | . | H | . | H | . | . | . | . | . | . | . | . | . | A | . | . | P | . | . | . | S | A | A | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
330c | 16 | . | . | T | C | . | . | . | . | . | . | . | . | . | A | . | . | . | . | . | . | . | . | A | . | K | . | . | . | . | . | . | . | . | . | . | . | . | . |
322a | 32 | . | H | . | . | . | . | . | . | . | . | . | . | . | A | . | . | . | R | . | . | . | . | A | . | . | . | . | D | . | . | . | . | . | . | . | . | . | . |
337c | 32 | . | H | . | . | R | . | . | . | . | . | . | . | . | A | . | . | . | . | T | . | . | . | A | . | K | . | . | . | . | . | . | Y | . | . | . | . | . | . |
342c2 | 32 | . | . | . | . | . | . | . | . | . | I | . | . | . | A | ∗ | . | . | R | T | . | . | . | A | . | . | . | . | . | . | Q | . | . | . | . | . | . | . | . |
345a2 | 48 | . | . | . | . | R | . | . | . | . | . | . | . | . | A | . | . | . | R | T | . | S | A | A | . | K | . | D | . | . | . | . | . | . | . | . | . | I | . |
349c2 | 48 | . | . | . | H | . | . | . | . | . | I | . | . | . | A | . | . | . | . | T | . | . | . | A | . | K | . | . | . | . | . | . | . | . | . | . | . | . | . |
73c | 32 | . | . | . | C | . | . | . | . | . | . | D | . | . | A | . | . | . | . | . | . | . | . | A | . | K | . | . | . | . | . | . | . | . | . | . | . | . | . |
7a | 48 | . | . | . | . | . | . | ∗ | . | . | . | . | . | . | A | . | . | . | R | Y | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
22a was arbitrarily chosen as reference strain.
., same as for reference strain.
∗, stop codon.