Table 1.
Timelines.
| Case 1 | |
|---|---|
| Index date | A 66-year-old male with ischemic cardiomyopathy and recurrent VTs requiring therapy from ICD |
| 1,5,11 months | Repeated ineffective catheter ablations due to intramural location of the substrate |
| 18 months | First SBRT with continuing recurrences of VT |
| 34 months | Remapping after the first SBRT |
| 38 months | Second SBRT, after 3 months VT disappeared |
| 69 months | Last follow-up visit, no arrhythmias |
| Case 2 | |
| Index date | A 34-year-old patient with an intramyocardial fibroma (60 × 40 × 25 mm) in the inferolateral wall of the left ventricle and recurrent VTs of different morphologies |
| 6 months | Empirical circumferential epicardial cryoablation around the tumor, 6 months without recurrences of VT |
| 13 months | Catheter ablation for recurrences of 2 morphologies of VT, one non-inducible, other almost incessant |
| 14 months | First SBRT, within 6 months all arrhythmias gradually disappeared |
| 38 months | v Re-do catheter ablation, without elimination of VT due to intramural substrate located in the opposite side of the tumor |
| 38 months | Second SBRT, within 3 months VT disappeared |
| 60 months | Last follow-up visit, no arrhythmias |
| Case 3 | |
| Index date | A77-year-old male with non-ischemic cardiomyopathy, aortic valve replacement and fibrosis in basal region of left ventricle and sporadic interventions of ICD |
| 70 months | Repeated catheter ablation for electrical storm |
| 71 months | First SBRT, arrhythmias less frequent |
| 73 months | Re-do catheter ablation for VT recurrences in basal septal region above the previous SBRT, non-inducibility |
| 75 months | Second SBRT for incessant VT, leading to slowing VT to 100 bpm |
| 76 months | Re-do catheter ablation in the basal septum, non-inducibility |
| 77 months | Progression of heart failure and cachexia, death |