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. Author manuscript; available in PMC: 2022 Apr 12.
Published in final edited form as: Wound Repair Regen. 2021 Nov 27;30(1):82–99. doi: 10.1111/wrr.12984

FIGURE 1.

FIGURE 1

Bg, mice have delayed wound healing. (A) Representative serial images of WT and Bg splinted, excisional wounds over the course of 2 weeks. Scale bar = 5 mm. (B) Planimetry measurements taken from serial images over time (n = 17 per group) show significantly less wound closure in Bg mice at 3, 10, and 14 days post procedure (p = 0.0030, p = 0.0017, and p = 0.0082, respectively). (C) Analysis of time needed until wounds were healed (n = 6 per group). Bg mice required 16.7 ± 2.1 days to heal, compared to WT mice which required 13.7 ± 1.0 days (p = 0.0098). (D) Mechanical testing of normal skin and scar tissue, 28 days post procedure (n = 9 per group). Scar tissue had a significant loss in maximum stress for both genotypes (p = 0.0378 for WT and p = 0.0169 for Bg). (E) Bg scar tissue was significantly stiffer than normal skin (p = 0.0444) while WT tissue demonstrated similar stiffness values between scar and normal skin. *p ≤ 0.05, **p ≤ 0.01 [Color figure can be viewed at wileyonlinelibrary.com]