Table 1.
Canalization versus decanalization model based on the departure of delta observed from delta expected in SD units, for CAD, T2D, obesity, DEP, and IBD.
| Trait | Description | Category | DeltaObs | DeltaExpect | Obs-Exp Departure | Model |
|---|---|---|---|---|---|---|
| CAD | Gender | Early life factors | 0.276 | 0.149 | 3.884 | Decanalization |
| CAD | Father still alive | Familial | 0.276 | 0.192 | 2.572 | Decanalization |
| CAD | Avg weekly beer and cider | Lifestyle | 0.167 | 0.087 | 2.450 | Decanalization |
| T2D | Father has diabetes | Familial | 0.150 | 0.081 | 3.006 | Decanalization |
| T2D | Alcohol intake frequency | Lifestyle | 0.149 | 0.089 | 2.639 | Decanalization |
| T2D | Nap during the day | Lifestyle | 0.199 | 0.142 | 2.477 | Decanalization |
| T2D | No. of days vigorous act | Lifestyle | 0.102 | 0.053 | 2.107 | Decanalization |
| T2D | No. of hours of work in a week | Lifestyle | 0.042 | −0.006 | 2.068 | Decanalization |
| T2D | Walk pace | Lifestyle | 0.177 | 0.131 | 2.002 | Decanalization |
| BMIObesity | Walk pace | Lifestyle | 0.290 | 0.238 | 2.988 | Decanalization |
| BMIObesity | Duration of walks | Lifestyle | 0.061 | 0.012 | 2.823 | Decanalization |
| BMIObesity | Mothers age | Familial | 0.045 | 0.002 | 2.446 | Decanalization |
| BMIObesity | Birth weight | Early life factors | 0.082 | 0.044 | 2.168 | Decanalization |
| BMIObesity | Maternal smoking at birth | Early life factors | 0.100 | 0.063 | 2.131 | Decanalization |
| BMIObesity | Mother has diabetes | Familial | 0.107 | 0.070 | 2.090 | Decanalization |
| BMIObesity | Father still alive | Familial | 0.016 | 0.054 | −2.207 | Canalization |
| BMIObesity | Cheese intake | Diet | 0.003 | 0.042 | −2.259 | Canalization |
| BMIObesity | Body size at age 10 | Early life factors | 0.115 | 0.155 | −2.328 | Canalization |
| BMIObesity | Age asthma diagnosed | General health | 0.044 | 0.088 | −2.538 | Canalization |
| BMIObesity | Jobs w/heavy physical work | Lifestyle | −0.030 | 0.033 | −3.615 | Canalization |
| WHRObesity | Body size at age 10 | Early life factors | 0.072 | 0.005 | 3.459 | Decanalization |
| WHRObesity | Father has diabetes | Familial | 0.064 | 0.008 | 2.925 | Decanalization |
| WHRObesity | Loneliness | Psychosocial | 0.037 | −0.011 | 2.530 | Decanalization |
| WHRObesity | Seen psychiatrist nerves | Psychosocial | 0.031 | −0.011 | 2.203 | Decanalization |
| WHRObesity | Type of accommodation | Socioeconomic | 0.042 | 0.001 | 2.149 | Decanalization |
| WHRObesity | Number of children fathered | Familial | 0.020 | −0.020 | 2.120 | Decanalization |
| WHRObesity | No. of vehicles in household | Socioeconomic | 0.028 | −0.011 | 2.064 | Decanalization |
| WHRObesity | Length of mobile phone use | Lifestyle | −0.044 | −0.001 | −2.267 | Canalization |
| WHRObesity | Time spent driving | Lifestyle | −0.041 | 0.011 | −2.699 | Canalization |
| WHRObesity | Alcohol intake frequency | Lifestyle | −0.061 | 0.011 | −3.767 | Canalization |
| Depression | Duration of vigorous act | Lifestyle | 0.034 | −0.002 | 2.426 | Decanalization |
| Depression | Mothers age | Familial | 0.037 | 0.004 | 2.249 | Decanalization |
| Depression | Tension | Psychosocial | 0.006 | 0.044 | −2.532 | Canalization |
| Depression | Avg total household income | Socioeconomic | −0.034 | 0.003 | −2.540 | Canalization |
| IBD | Sibling blood pressure | Familial | 0.014 | −0.007 | 2.596 | Decanalization |
| IBD | Bread type | Diet | 0.037 | 0.016 | 2.554 | Decanalization |
| IBD | Seen psychiatrist nerves | Psychosocial | 0.014 | −0.006 | 2.427 | Decanalization |
| IBD | Birth weight of first child | Familial | 0.016 | –0.0005 | 2.064 | Decanalization |