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. 2022 Mar 29;13:858423. doi: 10.3389/fimmu.2022.858423

Figure 1.

Figure 1

Characterization of extracellular vesicles (EVs) derived from Tasmanian devil serum. (A) Transmission electron microscopy images for EVs isolated from the serum of healthy control wild devils from an isolated disease-free population (n=4), latent DFTD devils (n=4) and DFTD infected devils (n=4). Red arrows indicate EV structures. (B) Size distribution profiles determined by nanoparticle tracking analysis (NTA) of EVs isolated from the serum of captive (n=4) and wild (n=4) healthy control devils, latent DFTD devils (n=4), and DFTD infected devils in early (n=4), medium (n=4) and late stages (n=4). Shaded areas represent 95% confidence intervals. (C) EV concentrations of the same NTA groups. Error bars represent 95% confidence intervals. (D) Heat map of intensity values of commonly recovered EV proteins, and (E) serum contaminants (albumin and five lipoproteins) found in EV samples derived from healthy controls (captive and wild) devils (n=27), latent DFTD devils (n=15), and devils in early (n=17), medium (n=15), and late (n=13) stages of DFTD.